Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9364315 | 0.93 | NPSR1 (0.42) | SMN1; SMN2HPGDNPSR1GAAKDM4E | |
| SCHEMBL9368993 | 0.84 | ADORA3 (0.45) | SMN1; SMN2MGLLHRH2HRH1LMNA | |
| SCHEMBL9118263 | 0.81 | NPSR1 (0.59) | SMN1; SMN2HPGDNPSR1GAAKDM4E | |
| SCHEMBL9367544 | 0.81 | TSHR (0.47) | SMN1; SMN2HPGDNPSR1KDM4EHTT | |
| SCHEMBL9369053 | 0.79 | ALDH1A1 (0.39) | SMN1; SMN2HPGDLMNAMAPTALDH1A1 | |
| SCHEMBL9364303 | 0.78 | HPGD (0.40) | SMN1; SMN2HPGDNPSR1GAAKDM4E | |
| SCHEMBL9363815 | 0.76 | NPSR1 (0.48) | SMN1; SMN2HPGDNPSR1GAAKDM4E | |
| SCHEMBL9364038 | 0.76 | PKM (0.47) | NPSR1GAAKDM4EHTTTSHR | |
| SCHEMBL9364015 | 0.74 | HSP90AA1 (0.42) | SMN1; SMN2HPGDNPSR1GAAKDM4E | |
| SCHEMBL9364030 | 0.74 | HPGD (0.43) | SMN1; SMN2HPGDNPSR1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0451654-B1 | Use of N-alkylated 1,4-dihydropyridine carboxylic acid esters as drugs, new compounds and process for their preparation | BAYER AG (DE) | 1994-09-07 | — | — | EP | claimed |
| EP-0451654-A2 | Use of N-alkylated 1,4-dihydropyridine carboxylic acid esters as drugs, new compounds and process for their preparation | BAYER AG (DE) | 1991-10-16 | — | — | EP | claimed |
| EP-0451654-B1 | Use of N-alkylated 1,4-dihydropyridine carboxylic acid esters as drugs, new compounds and process for their preparation | BAYER AG (DE) | 1994-09-07 | — | — | EP | disclosed |
| EP-0451654-A2 | Use of N-alkylated 1,4-dihydropyridine carboxylic acid esters as drugs, new compounds and process for their preparation | BAYER AG (DE) | 1991-10-16 | — | — | EP | disclosed |