Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29183917 | 0.77 | CYP1A2 (0.51) | SMN1; SMN2LMNAALDH1A1MAPTHTT | |
| SCHEMBL8020285 | 0.74 | ELANE (0.39) | POLBSMN1; SMN2LMNAALDH1A1MAPK1 | |
| SCHEMBL13436803 | 0.74 | MEN1 (0.50) | POLBSMN1; SMN2GAAL3MBTL1LMNA | |
| SCHEMBL4842407 | 0.73 | L3MBTL1 (0.41) | POLBSMN1; SMN2GAAMGAMSI | |
| SCHEMBL27974053 | 0.73 | POLB (0.53) | POLBSMN1; SMN2GAAMGAMSI | |
| SCHEMBL5099644 | 0.72 | DAO (0.50) | GAAMGAMSIMGAM2LMNA | |
| SCHEMBL10952665 | 0.72 | MEN1 (0.36) | POLBSMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL5312679 | 0.71 | NLRP3 (0.59) | POLBSMN1; SMN2GAAMGAMSI | |
| SCHEMBL6976089 | 0.71 | SMN1; SMN2 (0.47) | POLBSMN1; SMN2GAAMGAMSI | |
| SCHEMBL4840983 | 0.70 | ALDH1A1 (0.43) | POLBSMN1; SMN2GAAMGAMSI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409163-B1 | Novel cyclic vinylogous N-hydroxy-N-methylureas useful as 5-lipoxygenase inhibitors | MERRELL DOW PHARMA (US) | 1994-12-21 | — | — | EP | disclosed |