SCHEMBL9367109

SCHEMBL9367109

CN(C)C(=O)c1ccc(C(F)F)nc1S(=O)(=O)NC(C)(C)C

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF18A Q8NI77 2/20 0.34
ALOX5AP P20292 2/20 0.32
FEN1 P39748 2/20 0.32
CDK1 P06493 1/20 0.32
CNR2 P34972 1/20 0.31
NAMPT P43490 1/20 0.31
KEAP1 Q14145 1/20 0.31
ALDH1A1 P00352 2/20 0.30
HPGD P15428 2/20 0.30
CXCR2 P25025 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2C9 P11712 1/20 0.30
MAPK1 P28482 1/20 0.30
PARG Q86W56 1/20 0.30
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
NPC1 O15118 1/20 0.30
LMNA P02545 1/20 0.30
MAPT P10636 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9364237 0.85 MAPT (0.37) KIF18AALDH1A1HPGDKDM4EMEN1
SCHEMBL9363783 0.83 KIF18A (0.39) KIF18AALOX5APFEN1CDK1ALDH1A1
SCHEMBL9363538 0.81 LIPC (0.33) KEAP1KDM4EMEN1NPC1RAB9A
SCHEMBL9368610 0.80 CDK1 (0.35) CDK1KEAP1ALDH1A1CYP2C9KDM4E
SCHEMBL9118803 0.75 KIF18A (0.38) KIF18AALOX5APFEN1NAMPTKEAP1
SCHEMBL9364170 0.73 GAA (0.37) KIF18AALDH1A1HPGDKDM4EMEN1
SCHEMBL9363588 0.72 CDK1 (0.59) CDK1MEN1MAPTKMT2ASMN1; SMN2
SCHEMBL8804447 0.69 MEN1 (0.44) ALOX5APFEN1KEAP1HPGDCXCR2
SCHEMBL10516642 0.69 KIF18A (0.43) KIF18AALOX5APFEN1ALDH1A1HPGD
SCHEMBL9710189 0.68 ACLY (0.43) KIF18AALDH1A1CYP3A4CYP2C9MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0388994-B1 Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds ISHIHARA SANGYO KAISHA (JP) 1994-10-05 EP disclosed
EP-0388994-A1 Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds ISHIHARA SANGYO KAISHA, LTD. (JP) 1990-09-26 EP disclosed
EP-0232067-A2 Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds ISHIHARA SANGYO KAISHA LTD. (JP) 1987-08-12 EP disclosed