SCHEMBL9364170

SCHEMBL9364170

COC(=O)c1ccc(C(Br)Br)nc1S(=O)(=O)NC(C)(C)C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.37
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA5A P35218 1/20 0.35
CA9 Q16790 1/20 0.35
MAPT P10636 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
KIF18A Q8NI77 1/20 0.35
ALDH1A1 P00352 2/20 0.34
TUBB4A P04350 1/20 0.34
TUBB P07437 1/20 0.34
TUBA3C P0DPH7 1/20 0.34
TUBA1B P68363 1/20 0.34
TUBA4A P68366 1/20 0.34
TUBB4B P68371 1/20 0.34
TUBB3 Q13509 1/20 0.34
TUBB2A Q13885 1/20 0.34
TUBB8 Q3ZCM7 1/20 0.34
TUBA3E Q6PEY2 1/20 0.34
TUBA1A Q71U36 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9364237 0.88 MAPT (0.37) GAACA1CA2CA5ACA9
SCHEMBL9367060 0.82 GAA (0.43) GAACA1CA2CA5ACA9
SCHEMBL8540548 0.80 TUBB4A (0.50) GAAMAPTNPSR1KIF18AALDH1A1
SCHEMBL9367017 0.79 GAA (0.37) GAACA1CA2CA5ACA9
SCHEMBL30185608 0.74 NPC1 (0.50) GAACA1CA2CA9MAPT
SCHEMBL9117916 0.74 SLC40A1 (0.48) GAACA1CA2CA5ACA9
SCHEMBL9367109 0.73 KIF18A (0.34) MAPTKIF18AALDH1A1KMT2AMEN1
SCHEMBL10516642 0.70 KIF18A (0.43) GAACA1CA2CA9MAPT
SCHEMBL29295507 0.70 NR4A2 (0.43) GAACA1CA2CA5ACA9
SCHEMBL9710189 0.69 ACLY (0.43) MAPTNPSR1KIF18AALDH1A1TUBB4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0388994-B1 Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds ISHIHARA SANGYO KAISHA (JP) 1994-10-05 EP disclosed
EP-0388994-A1 Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds ISHIHARA SANGYO KAISHA, LTD. (JP) 1990-09-26 EP disclosed
EP-0232067-A2 Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds ISHIHARA SANGYO KAISHA LTD. (JP) 1987-08-12 EP disclosed