SCHEMBL9364237

SCHEMBL9364237

COC(=O)c1ccc(C(F)F)nc1S(=O)(=O)NC(C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.37
NPSR1 Q6W5P4 1/20 0.37
GAA P10253 4/20 0.36
KIF18A Q8NI77 1/20 0.36
TUBB4A P04350 1/20 0.36
TUBB P07437 1/20 0.36
TUBA3C P0DPH7 1/20 0.36
TUBA1B P68363 1/20 0.36
TUBA4A P68366 1/20 0.36
TUBB4B P68371 1/20 0.36
TUBB3 Q13509 1/20 0.36
TUBB2A Q13885 1/20 0.36
TUBB8 Q3ZCM7 1/20 0.36
TUBA3E Q6PEY2 1/20 0.36
TUBA1A Q71U36 1/20 0.36
TUBA1C Q9BQE3 1/20 0.36
TUBB6 Q9BUF5 1/20 0.36
TUBB2B Q9BVA1 1/20 0.36
TUBB1 Q9H4B7 1/20 0.36
CA1 P00915 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9364170 0.88 GAA (0.37) MAPTNPSR1GAAKIF18ATUBB4A
SCHEMBL9367109 0.85 KIF18A (0.34) MAPTKIF18AALDH1A1NPC1RAB9A
SCHEMBL8540548 0.82 TUBB4A (0.50) MAPTNPSR1GAAKIF18ATUBB4A
SCHEMBL9367060 0.81 GAA (0.43) MAPTNPSR1GAATUBB4ATUBB
SCHEMBL9367017 0.78 GAA (0.37) MAPTNPSR1GAATUBB4ATUBB
SCHEMBL6216992 0.73 NPC1 (0.54) MAPTGAACA1CA2CA9
SCHEMBL9117916 0.73 SLC40A1 (0.48) MAPTNPSR1GAACA1CA2
SCHEMBL19667440 0.72 SMN1; SMN2 (0.42) MAPTGAATUBB4ATUBBTUBA3C
SCHEMBL38663562 0.69 VCAM1 (0.42) NPSR1GAACA1CA2CA5A
SCHEMBL10516642 0.69 KIF18A (0.43) MAPTNPSR1GAAKIF18ACA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0388994-B1 Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds ISHIHARA SANGYO KAISHA (JP) 1994-10-05 EP disclosed
EP-0388994-A1 Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds ISHIHARA SANGYO KAISHA, LTD. (JP) 1990-09-26 EP disclosed
EP-0232067-A2 Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds ISHIHARA SANGYO KAISHA LTD. (JP) 1987-08-12 EP disclosed