Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983607 | 0.78 | HTR3E (0.43) | KDM4ECYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL3294513 | 0.72 | AKR1C3 (0.56) | RAB9AAKR1C3AKR1C2IDO1TDO2 | |
| SCHEMBL9372014 | 0.71 | NFE2L2 (0.44) | CYP3A4MAPTMEN1ALOX15MAPK1 | |
| SCHEMBL10451549 | 0.69 | MEN1 (0.53) | KDM4ECYP1A2CYP3A4MAPTCYP2C9 | |
| SCHEMBL4532731 | 0.65 | CYP3A4 (0.53) | KDM4ECYP3A4MAPT | |
| SCHEMBL13518527 | 0.65 | CYP3A4 (0.53) | KDM4ECYP3A4MAPT | |
| SCHEMBL6808918 | 0.65 | AKR1C3 (0.55) | KDM4ECYP2C19MEN1KMT2AAKR1C3 | |
| SCHEMBL4350401 | 0.65 | CYP1A1 (0.47) | KDM4ECYP3A4MAPTCYP2C19RAB9A | |
| SCHEMBL21555188 | 0.65 | PTGS2 (0.49) | MAPTRAB9AMEN1MAPK1KMT2A | |
| SCHEMBL29775476 | 0.65 | CYP1A1 (0.47) | KDM4ECYP3A4MAPTCYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |