Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | ESRRA | P11474 | 3/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981201 | 0.80 | LMNA (0.57) | NFE2L2RETNQO2MAPTHTT | |
| SCHEMBL7983283 | 0.78 | NQO2 (0.54) | NQO2PTGS1RXRA | |
| SCHEMBL29153453 | 0.74 | MAOB (0.68) | — | |
| SCHEMBL29153451 | 0.74 | MAOB (0.68) | — | |
| SCHEMBL9372017 | 0.72 | TNF (0.46) | NFE2L2MAPTLMNAMEN1MAPK1 | |
| SCHEMBL3294513 | 0.72 | AKR1C3 (0.56) | — | |
| SCHEMBL9367254 | 0.71 | KDM4E (0.44) | NFE2L2CYP3A4MAPTMEN1ALOX15 | |
| SCHEMBL10451549 | 0.69 | MEN1 (0.53) | NQO2CYP3A4MAPTLMNAHPGD | |
| SCHEMBL27769528 | 0.67 | MMP1 (0.47) | NFE2L2CXCL12NQO2MAPTHPGD | |
| SCHEMBL26936527 | 0.67 | TTR (0.67) | CXCL12ESRRACYP3A4MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |