Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9719736 | 0.98 | PARP1 (0.40) | PARP1ESR1ESR2GRIN2DGRIN3B | |
| SCHEMBL223841 | 0.84 | SLC6A3 (0.33) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL9727813 | 0.80 | SLC6A4 (0.40) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL10551331 | 0.76 | MAOA (0.44) | ESR1ESR2 | |
| SCHEMBL30280698 | 0.76 | GRIN2D (0.57) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL11336356 | 0.76 | LMNA (0.41) | — | |
| SCHEMBL224227 | 0.73 | TAAR1 (0.44) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL221821 | 0.73 | CCR5 (0.38) | ESR1ESR2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL10456976 | 0.72 | ESR1 (0.36) | ESR1ESR2GRIN2DGRIN3BGRIN1 | |
| Oxalic Acid SCHEMBL5154647 | 0.71 | KDM4E (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486385-B1 | Imidazole derivatives, process for their fabrication and pharmaceutical compositions containing them | ADIR (FR) | 1994-12-28 | — | — | EP | claimed |
| US-5173502-A | For treating depression, hypertension, parkinson*s disease, asthma, convulasions, platelet aggregation of metabolic disorders | ADIR ET COMPAGNIE (FR) | 1992-12-22 | — | — | US | claimed |
| EP-0486385-A1 | Imidazole derivatives, process for their fabrication and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-05-20 | — | — | EP | claimed |
| EP-0486385-B1 | Imidazole derivatives, process for their fabrication and pharmaceutical compositions containing them | ADIR (FR) | 1994-12-28 | — | — | EP | disclosed |
| EP-0486385-A1 | Imidazole derivatives, process for their fabrication and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-05-20 | — | — | EP | disclosed |