Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9368489 | 0.93 | DUSP3 (0.38) | GABRA1GABRG2GABRB3MAPK1CRHR1 | |
| SCHEMBL9371953 | 0.85 | NLRP3 (0.35) | MAPK1ALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL9368050 | 0.83 | NLRP3 (0.34) | MAPK1ALDH1A1HPGDTAS1R3TAS1R1 | |
| SCHEMBL9373305 | 0.80 | RORC (0.41) | ALDH1A1HPGDSMN1; SMN2ATMNLRP3 | |
| SCHEMBL9369273 | 0.79 | NLRP3 (0.37) | MAPK1ALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL9368867 | 0.78 | HPGD (0.40) | MAPK1ALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL9368764 | 0.76 | NLRP3 (0.33) | MAPK1ALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL9376548 | 0.76 | NLRP3 (0.39) | GABRA1GABRG2GABRB3MAPK1CRHR1 | |
| SCHEMBL9368573 | 0.75 | TDP1 (0.38) | MAPK1ALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL8744754 | 0.75 | NLRP3 (0.34) | MAPK1ALDH1A1HPGDSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377893-B1 | 3-Aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1994-04-06 | — | — | EP | disclosed |
| US-5186737-A | Herbicides | BAYER AKTIENGESELLSCHAFT (DE) | 1993-02-16 | — | — | US | disclosed |
| US-5045560-A | Insecticides, nematocides, fungicides, herbicides, human and veterinary medicine | BAYER AKTIENGESELLSCHAFT (DE) | 1991-09-03 | — | — | US | disclosed |
| EP-0377893-A2 | 3-Aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1990-07-18 | — | — | EP | disclosed |