Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9373260 | 0.92 | ITGB1 (0.39) | NLRP3GABRA1GABRG2GABRB3CRHR1 | |
| SCHEMBL9372436 | 0.84 | NLRP3 (0.43) | NLRP3GAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9368524 | 0.82 | NLRP3 (0.37) | NLRP3ALDH1A1SMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL9369588 | 0.81 | KMT2A (0.40) | NLRP3CRHR1GAAALOX12ALDH1A1 | |
| SCHEMBL9369583 | 0.80 | NLRP3 (0.40) | NLRP3ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9374168 | 0.80 | NLRP3 (0.40) | NLRP3ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL9372688 | 0.78 | F2 (0.40) | NLRP3CRHR1GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL9481206 | 0.77 | HPGD (0.40) | NLRP3ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL9368665 | 0.76 | PIN1 (0.47) | POLBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9368759 | 0.76 | GABRA1 (0.39) | NLRP3GABRA1GABRG2GABRB3CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377893-B1 | 3-Aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1994-04-06 | — | — | EP | disclosed |
| US-5186737-A | Herbicides | BAYER AKTIENGESELLSCHAFT (DE) | 1993-02-16 | — | — | US | disclosed |
| US-5045560-A | Insecticides, nematocides, fungicides, herbicides, human and veterinary medicine | BAYER AKTIENGESELLSCHAFT (DE) | 1991-09-03 | — | — | US | disclosed |
| EP-0377893-A2 | 3-Aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1990-07-18 | — | — | EP | disclosed |