Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | FRK | P42685 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27980049 | 0.76 | PTGS2 (0.58) | PTGS2PRKD3MAP4K4FRKMAPK9 | |
| SCHEMBL7475809 | 0.75 | TDP1 (0.53) | LMNATSHRAPAF1HTTMAPT | |
| SCHEMBL4064723 | 0.75 | PTGS2 (0.50) | PTGS2PRKD3MAP4K4FRKMAPK9 | |
| SCHEMBL4805174 | 0.74 | PTGS2 (0.63) | PTGS2PRKD3MAP4K4FRKMAPK9 | |
| SCHEMBL11424185 | 0.72 | PTGS2 (0.54) | PTGS2PRKD3MAP4K4FRKMAPK9 | |
| SCHEMBL9370596 | 0.72 | LMNA (0.43) | PTGS2PRKD3MAP4K4FRKMAPK9 | |
| SCHEMBL10615042 | 0.71 | PTGS2 (0.59) | PTGS2PRKD3MAP4K4FRKMAPK9 | |
| SCHEMBL9525213 | 0.71 | ALDH1A1 (0.44) | PTGS2LMNAMAPK13MAPK12MAPK11 | |
| SCHEMBL3836933 | 0.71 | PTGS2 (0.55) | PTGS2PRKD3MAP4K4FRKMAPK9 | |
| SCHEMBL20466312 | 0.71 | MAPK14 (0.60) | PTGS2PRKD3MAP4K4FRKMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5318984-A | Anticholesterol agents which inhibit acetyl coenzyme A transferase | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0372445-B1 | Imidazoles for the treatment of atherosclerosis | DU PONT MERCK PHARMA (US) | 1994-03-09 | — | — | EP | disclosed |
| US-5166214-A | Enzyme inhibitors for anticholesterol agents, enzyme inhibitor and cardiovascular disorders | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0372445-A1 | Imidazoles for the treatment of atherosclerosis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-06-13 | — | — | EP | disclosed |