Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525207 | 0.78 | MAPK14 (0.43) | ALDH1A1KDM4EMAPK14MAPK13MAPK12 | |
| SCHEMBL9370457 | 0.75 | FAAH (0.41) | ALDH1A1KDM4EL3MBTL1FAAH | |
| SCHEMBL9370600 | 0.71 | PTGS2 (0.50) | ALDH1A1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL9369651 | 0.71 | FAAH (0.40) | FAAH | |
| SCHEMBL9539522 | 0.70 | NPSR1 (0.50) | ALDH1A1KDM4EL3MBTL1LMNA | |
| SCHEMBL4838002 | 0.68 | ALDH1A1 (0.32) | ALDH1A1KDM4EFAAH | |
| SCHEMBL7925236 | 0.64 | PPARG (0.39) | ALDH1A1KDM4EL3MBTL1LMNA | |
| SCHEMBL13937116 | 0.62 | LMNA (0.60) | ALDH1A1KDM4EL3MBTL1LMNA | |
| SCHEMBL13587979 | 0.62 | MEN1 (0.47) | ALDH1A1KDM4EMAPK14FAAH | |
| SCHEMBL10967698 | 0.62 | ALDH1A1 (0.49) | ALDH1A1KDM4EL3MBTL1LMNAPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993001184-A1 | IMIDAZOLES INHIBITORS AS ACAT AND THROMBOXANE TXA2 | RHONE-POULENC RORER LIMITED (GB) | 1993-01-21 | — | — | WO | disclosed |
| EP-0522887-A1 | Imidazoles as ACAT- and thromboxane TxA2 inhibitors | RHONE-POULENC RORER LIMITED (GB) | 1993-01-13 | — | — | EP | disclosed |