Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 9/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9376993 | 0.79 | DYRK1A (0.51) | CYP1A2 | |
| SCHEMBL9378645 | 0.78 | GABRG2 (0.44) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL9376329 | 0.74 | MAPT (0.44) | HTTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL28020925 | 0.71 | IDO1 (0.48) | IDO1TDO2BIRC5CYP1A2CYP2C19 | |
| SCHEMBL7362648 | 0.70 | CAMKK2 (0.47) | ALDH1A1MEN1KMT2AEGFR | |
| SCHEMBL21805047 | 0.69 | IDO1 (0.47) | IDO1TDO2BIRC5BCHEACHE | |
| SCHEMBL30088096 | 0.69 | IDO1 (0.47) | IDO1TDO2BIRC5BCHEACHE | |
| SCHEMBL15606489 | 0.68 | CYP2A6 (0.56) | IDO1TDO2BIRC5BCHEACHE | |
| SCHEMBL31070756 | 0.68 | CYP2A6 (0.56) | IDO1TDO2BIRC5BCHEACHE | |
| SCHEMBL19051830 | 0.67 | ALDH1A1 (0.44) | IDO1TDO2BIRC5CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |