Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclopentane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.77 |
| ▸ | CA2 | P00918 | 2/20 | 0.77 |
| ▸ | BLM | P54132 | 2/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.77 |
| ▸ | CA5A | P35218 | 1/20 | 0.77 |
| ▸ | CA9 | Q16790 | 1/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyurea SCHEMBL9377620 | 1.00 | — | — | |
| Hydroxyurea SCHEMBL10966425 | 1.00 | — | — | |
| Hydroxyurea SCHEMBL5329855 | 0.88 | LMNA (1.00) | LMNATSHRNFKB1CA2BLM | |
| Hydroxyurea SCHEMBL4004 | 0.88 | — | — | |
| Hydroxyurea SCHEMBL93814 | 0.88 | LMNA (1.00) | LMNATSHRNFKB1CA2BLM | |
| Hydroxyurea SCHEMBL23274911 | 0.84 | — | — | |
| Hydroxyurea SCHEMBL306433 | 0.84 | — | — | |
| Hydroxyurea SCHEMBL28868410 | 0.84 | — | — | |
| Hydroxyurea SCHEMBL15011410 | 0.84 | — | — | |
| Hydroxyurea SCHEMBL308240 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150040-B1 | Imidazodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 1994-08-31 | — | — | EP | disclosed |
| EP-0150040-A2 | Imidazodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1985-07-31 | — | — | EP | disclosed |