Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8132638 | 0.89 | LMNA (0.59) | LMNANPSR1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL10123547 | 0.81 | LMNA (0.60) | LMNANPSR1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL12877767 | 0.77 | LMNA (0.64) | LMNANPSR1RAB9APOLBSMN1; SMN2 | |
| Bromide SCHEMBL9690249 | 0.76 | RAB9A (0.59) | LMNANPSR1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL24000166 | 0.73 | ALDH1A1 (0.65) | LMNANPSR1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL10109757 | 0.73 | LMNA (0.59) | LMNANPSR1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL6885992 | 0.73 | LMNA (0.77) | LMNANPSR1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL12862543 | 0.73 | LMNA (0.59) | LMNANPSR1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL8598953 | 0.73 | NPC1 (0.58) | LMNARAB9APOLBSMN1; SMN2KMT2A | |
| SCHEMBL12301768 | 0.72 | LMNA (0.75) | LMNANPSR1RAB9APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625978-A1 | PIPERAZINE AND PIPERIDINE DERIVATIVES, AND THEIR USE AS ANTIPSYCHOTICS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-30 | — | — | EP | disclosed |
| WO-1993016073-A1 | PIPERAZINE AND PIPERIDINE DERIVATIVES, AND THEIR USE AS ANTIPSYCHOTICS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-08-19 | — | — | WO | disclosed |