Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10123547 | 0.81 | LMNA (0.60) | RAB9ALMNANPSR1SMN1; SMN2MAPK1 | |
| SCHEMBL8132638 | 0.80 | LMNA (0.59) | RAB9ALMNANPSR1SMN1; SMN2MAPK1 | |
| SCHEMBL12877767 | 0.77 | LMNA (0.64) | RAB9ALMNANPSR1SMN1; SMN2MAPK1 | |
| SCHEMBL9377652 | 0.76 | LMNA (0.55) | RAB9ALMNANPSR1SMN1; SMN2MAPK1 | |
| SCHEMBL10698694 | 0.74 | ADRA1A (0.62) | LMNASMN1; SMN2TSHR | |
| SCHEMBL24000166 | 0.73 | ALDH1A1 (0.65) | RAB9ALMNANPSR1SMN1; SMN2MAPK1 | |
| SCHEMBL6885992 | 0.73 | LMNA (0.77) | RAB9ALMNANPSR1SMN1; SMN2MAPK1 | |
| SCHEMBL10109757 | 0.73 | LMNA (0.59) | RAB9ALMNANPSR1SMN1; SMN2MAPK1 | |
| SCHEMBL12862543 | 0.73 | LMNA (0.59) | RAB9ALMNANPSR1SMN1; SMN2MAPK1 | |
| SCHEMBL3973342 | 0.73 | NPC1 (0.58) | RAB9ALMNASMN1; SMN2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |