Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11640576 | 0.85 | OPRL1 (0.48) | OPRL1ALDH1A1OPRM1OPRK1SLC6A4 | |
| SCHEMBL11640983 | 0.78 | OPRL1 (0.53) | OPRL1OPRM1OPRK1LMNASLC6A4 | |
| SCHEMBL28393240 | 0.77 | MAOA (0.47) | ALDH1A1GAAMAOAMAOBKMT2A | |
| SCHEMBL25502421 | 0.77 | TP53 (0.48) | ALDH1A1GAAMAOAMAOBKMT2A | |
| SCHEMBL23991954 | 0.77 | OPRL1 (0.48) | OPRL1ALDH1A1OPRM1OPRK1SLC6A4 | |
| SCHEMBL12659470 | 0.77 | L3MBTL1 (0.61) | OPRL1ALDH1A1GAAOPRM1OPRK1 | |
| SCHEMBL11640502 | 0.75 | LMNA (0.49) | OPRL1OPRM1OPRK1LMNASLC6A4 | |
| SCHEMBL11636971 | 0.75 | ALDH1A1 (0.54) | OPRL1ALDH1A1OPRM1OPRK1LMNA | |
| SCHEMBL11640010 | 0.74 | SLC6A4 (0.57) | OPRL1OPRM1OPRK1LMNASLC6A4 | |
| SCHEMBL23993157 | 0.73 | OPRL1 (0.48) | OPRL1ALDH1A1OPRM1OPRK1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320992-B1 | Triazolodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 1994-07-27 | — | — | EP | disclosed |
| US-4959361-A | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists | HOFFMANN-LA ROCHE INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0320992-A2 | Triazolodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-06-21 | — | — | EP | disclosed |