Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11341497 | 0.79 | CSNK2A1 (0.45) | CSNK2A1MEN1KMT2AGFERMAPT | |
| SCHEMBL1421936 | 0.79 | CSNK2A1 (0.61) | CSNK2A1MEN1KMT2AGFERCA1 | |
| SCHEMBL31695396 | 0.79 | CSNK2A1 (0.61) | CSNK2A1MEN1KMT2AGFERCA1 | |
| Potassium Ion SCHEMBL9418199 | 0.78 | CSNK2A1 (0.64) | CSNK2A1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL9380353 | 0.78 | CSNK2A1 (0.59) | CSNK2A1MEN1KMT2AGFERCA1 | |
| SCHEMBL8123981 | 0.78 | CSNK2A1 (0.44) | CSNK2A1MEN1KMT2AGFERMAPT | |
| SCHEMBL4174657 | 0.78 | PARP1 (0.44) | CSNK2A1MEN1KMT2AGFERMAPT | |
| SCHEMBL6233998 | 0.77 | CSNK2A1 (0.47) | CSNK2A1MEN1KMT2AMAPTHDAC7 | |
| Zinc Ion SCHEMBL27988718 | 0.77 | CSNK2A1 (0.47) | CSNK2A1MEN1KMT2AMAPTHDAC7 | |
| Potassium Ion SCHEMBL5597537 | 0.76 | KAT6A (0.43) | CSNK2A1MEN1KMT2ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278176-B1 | Compounds having antitumour and antibacterial properties | WARNER LAMBERT CO (US) | 1994-03-09 | — | — | EP | disclosed |
| US-5281620-A | Alkyl substituted xanthenone-4-acetic acid | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1994-01-25 | — | — | US | disclosed |
| EP-0278176-A2 | Compounds having antitumour and antibacterial properties | WARNER-LAMBERT COMPANY (US) | 1988-08-17 | — | — | EP | disclosed |