Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | XBP1 | P17861 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2791470 | 0.84 | RAB9A (0.43) | RAB9ANPC1MITFNPSR1LMNA | |
| SCHEMBL9377883 | 0.83 | ALDH1A1 (0.47) | LMNAHTTMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL9374240 | 0.82 | ALDH1A1 (0.46) | LMNAHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL9375592 | 0.75 | SIGMAR1 (0.41) | SMN1; SMN2ALDH1A1TP53CYP1A2CYP3A4 | |
| SCHEMBL13507986 | 0.73 | RAB9A (0.34) | RAB9ANPC1MITFNPSR1LMNA | |
| SCHEMBL9374898 | 0.72 | SIGMAR1 (0.48) | MEN1KMT2AALDH1A1TP53CYP1A2 | |
| SCHEMBL15355355 | 0.71 | ALDH1A1 (0.43) | MEN1KMT2ASMN1; SMN2HDAC9ALDH1A1 | |
| SCHEMBL24926025 | 0.71 | ALDH1A1 (0.43) | HTTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9374939 | 0.71 | OPRM1 (0.43) | MEN1KMT2AALDH1A1TP53CYP1A2 | |
| SCHEMBL1404036 | 0.70 | MITF (0.39) | MITFMEN1KMT2AHDAC9KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0336228-B1 | Tetrahydroisoquinolines and tetrahydrobenzazepines and a process for the preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-09 | — | — | EP | disclosed |
| US-5059608-A | Anticonvulsants, antiischemic agents | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1991-10-22 | — | — | US | disclosed |
| EP-0336228-A1 | Tetrahydroisoquinolines and tetrahydrobenzazepines and a process for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-10-11 | — | — | EP | disclosed |