Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | PLK1 | P53350 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.40 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12486470 | 0.77 | KDM4E (0.69) | KDM4EPLK1ALDH1A1GAAHPGD | |
| SCHEMBL10366239 | 0.76 | ICMT (0.44) | KDM4EPLK1GAAMEN1KMT2A | |
| SCHEMBL11015329 | 0.73 | GAA (0.45) | KDM4EGAASIGMAR1OPRM1OPRK1 | |
| SCHEMBL7302304 | 0.71 | KDM4E (0.61) | KDM4EPLK1ALDH1A1GAAHPGD | |
| SCHEMBL2679599 | 0.70 | KDM4E (1.00) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL7301108 | 0.70 | KDM4E (0.56) | KDM4EPLK1ALDH1A1GAAHPGD | |
| SCHEMBL9381025 | 0.69 | CNR1 (0.51) | KDM4EPLK1TSHRLMNA | |
| SCHEMBL3724622 | 0.69 | HTR3A (0.56) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL3724624 | 0.69 | HTR3A (0.56) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL7490360 | 0.69 | HTR3A (0.56) | KDM4EALDH1A1GAAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603220-A1 | AZABICYCLIC COMPOUNDS AS 5-HT 4? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-06-29 | — | — | EP | disclosed |