Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.40 |
| ▸ | PLK1 | P53350 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11015329 | 0.85 | GAA (0.45) | SIGMAR1OPRM1OPRK1OPRL1GAA | |
| SCHEMBL9385384 | 0.76 | KDM4E (0.54) | MEN1KMT2ASIGMAR1OPRM1OPRK1 | |
| SCHEMBL8353634 | 0.75 | ICMT (0.43) | ICMTMEN1KMT2APLK1FABP4 | |
| SCHEMBL4990643 | 0.73 | HTR6 (0.58) | SIGMAR1OPRM1OPRK1OPRL1GAA | |
| SCHEMBL9493084 | 0.72 | MEN1 (0.58) | MEN1KMT2AOPRM1OPRK1PLK1 | |
| SCHEMBL10366800 | 0.70 | OPRK1 (0.49) | MEN1KMT2AOPRM1OPRK1GAA | |
| SCHEMBL30958421 | 0.68 | ICMT (0.62) | ICMTMEN1KMT2AGAAKDM4E | |
| SCHEMBL588980 | 0.68 | ICMT (0.62) | ICMTMEN1KMT2AGAAKDM4E | |
| SCHEMBL24117805 | 0.68 | PTGDR2 (0.53) | MEN1KMT2AOPRM1OPRK1PLK1 | |
| SCHEMBL1991929 | 0.68 | ICMT (0.57) | ICMTPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147085-B1 | SUBSTITUTED TRANS-1.2-DIAMINOCYCLOHEXYL AMIDE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1990-03-14 | — | — | EP | disclosed |