Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11069441 | 0.79 | MAPT (0.64) | DRD2MAPTTP53KDM4EALDH1A1 | |
| SCHEMBL9386389 | 0.78 | DRD2 (0.56) | DRD2MAPTTP53TDP1ALDH1A1 | |
| SCHEMBL11072138 | 0.78 | L3MBTL1 (0.61) | DRD2MAPTALDH1A1POLBLMNA | |
| SCHEMBL4670427 | 0.75 | ADORA2B (0.41) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5915124 | 0.74 | DRD2 (1.00) | DRD2HSD17B10KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9384727 | 0.74 | ADORA2B (0.40) | MAPTKDM4EALDH1A1LMNAGFER | |
| SCHEMBL10466230 | 0.73 | DRD2 (0.50) | DRD2MAPTTP53TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11218267 | 0.73 | DRD2 (0.97) | DRD2HSD17B10KMT2AMEN1 | |
| SCHEMBL9038067 | 0.73 | DRD2 (0.59) | DRD2MAPTTP53ALDH1A1USP2 | |
| SCHEMBL4672126 | 0.72 | NPBWR1 (0.42) | DRD2MAPTTDP1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0331232-B1 | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols | JANSSEN PHARMACEUTICA NV (BE) | 1994-05-18 | — | — | EP | disclosed |
| US-4931444-A | FOR LEUKOTRIENE-MEDIATED DISEASES AND DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-05 | — | — | US | disclosed |
| EP-0331232-A2 | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-09-06 | — | — | EP | disclosed |