Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672123 | 0.86 | MAPKAPK2 (0.46) | NPBWR1SMN1; SMN2LMNAMAPTDRD2 | |
| SCHEMBL4672086 | 0.84 | KCNJ1 (0.53) | SMN1; SMN2LMNAMAPTMAPK1 | |
| SCHEMBL4673358 | 0.84 | MAOB (0.46) | GSK3AGSK3BLMNASIGMAR1ROCK2 | |
| SCHEMBL4670427 | 0.75 | ADORA2B (0.41) | SMN1; SMN2CYP19A1LMNAROCK2 | |
| SCHEMBL6300285 | 0.75 | NPC1 (0.41) | SIGMAR1DRD2 | |
| SCHEMBL4670482 | 0.75 | DHODH (0.36) | NPBWR1LMNAROCK2CYP2C9TDP1 | |
| Hydrochloric Acid SCHEMBL9384727 | 0.74 | ADORA2B (0.40) | SMN1; SMN2CYP19A1LMNAMAPTROCK2 | |
| SCHEMBL9385608 | 0.72 | DRD2 (0.58) | SMN1; SMN2LMNAMAPTTDP1DRD2 | |
| SCHEMBL4673352 | 0.70 | MAPK1 (0.50) | ROCK2MAPK1 | |
| Water SCHEMBL4672111 | 0.69 | ADRB2 (0.42) | SMN1; SMN2CYP19A1MAPTNPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054881-B1 | NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS | BAYER CORP (US) | 2008-07-30 | — | — | EP | disclosed |