SCHEMBL9385685

SCHEMBL9385685

COc1cc(OC)nc(SC(C(=O)NS(=O)(=O)c2ncccn2)C(C)(C)C)n1

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
GAA P10253 1/20 0.34
CYP1A2 P05177 1/20 0.33
TP53 P04637 1/20 0.32
GLA P06280 1/20 0.32
MAPT P10636 1/20 0.32
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9213410 0.88 LGALS8 (0.36) GAATP53GLAMAPT
SCHEMBL9320988 0.81 CYP1A2 (0.34) LMNASMN1; SMN2GAACYP1A2KDM4E
SCHEMBL9214908 0.81 LGALS8 (0.36) GAATP53GLAMAPT
SCHEMBL9145496 0.76 LMNA (0.38) LMNASMN1; SMN2GAACYP1A2KDM4E
SCHEMBL8538415 0.75 LMNA (0.37) LMNASMN1; SMN2GAACYP1A2KDM4E
SCHEMBL9385753 0.74 GSK3B (0.40) LMNASMN1; SMN2MAPTKDM4EALDH1A1
SCHEMBL9206886 0.74 PPARA (0.39) SMN1; SMN2GAATP53GLAMAPT
SCHEMBL9208674 0.73 CYP1A2 (0.33) LMNASMN1; SMN2GAACYP1A2KDM4E
SCHEMBL8537289 0.73 LMNA (0.35) LMNASMN1; SMN2GAACYP1A2KDM4E
SCHEMBL9122561 0.71 ALOX5 (0.32) GAACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-6016660-A None JP disclosed
JP-H0616660-A PYRIDINESULFONAMIDE DERIVATIVE, ITS PRODUCTION AND HERIBICIDE UBE IND LTD 1994-01-25 JP disclosed