Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | CTSC | P53634 | 1/20 | 0.46 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2309960 | 1.00 | GPR142 (0.48) | GPR142ALPIPKMPTGS1XIAP | |
| SCHEMBL2309947 | 1.00 | GPR142 (0.48) | GPR142ALPIPKMPTGS1XIAP | |
| SCHEMBL3004830 | 0.80 | CIT (0.54) | GPR142CITAKT1BACE1LTA4H | |
| SCHEMBL3004819 | 0.80 | CIT (0.54) | GPR142CITAKT1BACE1LTA4H | |
| SCHEMBL7094901 | 0.79 | ROCK2 (0.46) | GPR142ALPIPKMPTGS1XIAP | |
| Hydrochloric Acid SCHEMBL3002276 | 0.77 | ROCK1 (0.49) | GPR142CITAKT1BACE1ROCK2 | |
| Hydrochloric Acid SCHEMBL3002263 | 0.77 | ROCK1 (0.49) | GPR142CITAKT1BACE1ROCK2 | |
| SCHEMBL13715679 | 0.76 | MMP3 (0.56) | — | |
| SCHEMBL2528923 | 0.76 | ALDH1A1 (0.54) | HDAC8 | |
| SCHEMBL13411762 | 0.76 | ALPL (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620813-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES AS ANTAGONISTS OF PAF AND ANGIOTENSIN II | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1994-10-26 | — | — | EP | claimed |
| WO-1993014069-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES AS ANTAGONISTS OF PAF AND ANGIOTENSIN II | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-07-22 | — | — | WO | claimed |