Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.54 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9386461 | 0.81 | LTA4H (0.67) | LMNACHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL4972736 | 0.77 | LMNA (0.57) | LMNAMAPK1ALDH1A1TSHRPRMT1 | |
| SCHEMBL14592716 | 0.77 | CHEK2 (0.54) | LMNAMAPK1ALDH1A1TSHRPRMT1 | |
| SCHEMBL9384519 | 0.74 | HRH3 (0.47) | CHRNB2CHRNA5CHRNA7CHRNA4L3MBTL1 | |
| Hydrochloric Acid SCHEMBL9382050 | 0.74 | DRD4 (0.55) | LMNAMAPK1DRD2DRD4 | |
| SCHEMBL9209237 | 0.74 | LMNA (0.55) | LMNAMAPK1PKMALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL10900956 | 0.74 | MAPK1 (0.67) | LMNAMAPK1ALDH1A1TSHRPRMT1 | |
| SCHEMBL85313 | 0.74 | KCNH2 (0.46) | LMNACHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL9582505 | 0.73 | SIGMAR1 (0.51) | LMNADRD4HRH2 | |
| SCHEMBL9581725 | 0.73 | L3MBTL1 (0.55) | ALDH1A1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398426-B1 | Antirhinoviral (thio)morpholinyl and piperazinyl alkylphenol ethers | JANSSEN PHARMACEUTICA NV (BE) | 1994-03-09 | — | — | EP | disclosed |
| US-5070090-A | SUSTAINED RELEASE FROM CYCLODEXTRIN INCLUSION COMPOUND | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-03 | — | — | US | disclosed |
| EP-0398426-A1 | Antirhinoviral (thio)morpholinyl and piperazinyl alkylphenol ethers | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-11-22 | — | — | EP | disclosed |