Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394048 | 0.84 | ALDH1A1 (0.51) | ALDH1A1CYP1A2TSHRUSP2LMNA | |
| Hydrochloric Acid SCHEMBL612325 | 0.83 | ALDH1A1 (0.50) | ALDH1A1CYP1A2TSHRUSP2LMNA | |
| SCHEMBL7825503 | 0.80 | ALDH1A1 (0.38) | ALDH1A1CYP1A2TSHRUSP2LMNA | |
| SCHEMBL29127308 | 0.78 | CYP1A2 (0.52) | ALDH1A1CYP1A2TSHRUSP2LMNA | |
| SCHEMBL395803 | 0.77 | ALDH1A1 (0.59) | ALDH1A1CYP1A2TSHRUSP2LMNA | |
| SCHEMBL15456626 | 0.77 | TSHR (0.41) | ALDH1A1TSHRSMN1; SMN2GAA | |
| SCHEMBL98282 | 0.76 | ALDH1A1 (0.74) | ALDH1A1CYP1A2TSHRUSP2LMNA | |
| SCHEMBL2871721 | 0.76 | ALDH1A1 (0.74) | ALDH1A1CYP1A2TSHRUSP2LMNA | |
| SCHEMBL3421776 | 0.76 | ALDH1A1 (0.74) | ALDH1A1CYP1A2TSHRUSP2LMNA | |
| SCHEMBL10602483 | 0.76 | ALDH1A1 (0.74) | ALDH1A1CYP1A2TSHRUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868041-B2 | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof | XENOPORT, INC. (US) | 2011-01-11 | — | — | US | disclosed |
| US-20090270493-A1 | CYCLIC 1-(ACYLOXY)-ALKYL PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2009-10-29 | — | — | US | disclosed |
| US-7569576-B2 | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof | XENOPORT, INC. (US) | 2009-08-04 | — | — | US | disclosed |
| US-20060122125-A1 | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof | XENOPORT, INC. | 2006-06-08 | — | — | US | disclosed |
| US-7026351-B2 | Gamma-aminobutyric acid (GABA); prodrugs of gabapentin and/or pregabalin; for sustained release; for treatment of pain and epilepsy | XENOPORT, INC. (US) | 2006-04-11 | — | — | US | disclosed |
| US-20030236200-A1 | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof | XENOPORT, INC. | 2003-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270493-A1 | CYCLIC 1-(ACYLOXY)-ALKYL PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | GABRB1, GABRB3, GABRB2 | ALDH1A1 136/4885CYP1A2 346/4885TSHR 2603/4885 |
| US-20060122125-A1 | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof | GABRB1, GABRB3, GABRB2 | ALDH1A1 136/4885CYP1A2 346/4885TSHR 2603/4885 |
| US-20030236200-A1 | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof | GABRB1, GABRB3, GABRB2 | ALDH1A1 136/4885CYP1A2 346/4885TSHR 2603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.