Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | NPY1R | P25929 | 1/20 | 0.54 |
| ▸ | NPY2R | P49146 | 1/20 | 0.54 |
| ▸ | CTSV | O60911 | 2/20 | 0.52 |
| ▸ | CTSL | P07711 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9542154 | 0.84 | MAPT (0.50) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4011471 | 0.81 | ALDH1A1 (0.68) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL30312308 | 0.81 | ALDH1A1 (0.68) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL155013 | 0.80 | GABRA1 (0.70) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL29540314 | 0.80 | GABRA1 (0.70) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL26630415 | 0.78 | MAPT (0.56) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5260301 | 0.78 | VDR (0.49) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL12722533 | 0.78 | MAPT (0.59) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL11608571 | 0.76 | MAPT (0.54) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4825677 | 0.76 | MAPT (0.54) | MAPTALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328922-A | Anxiolytic and antidepressant activity | BEECHAM GROUP P.L.C. (GB) | 1994-07-12 | — | — | US | disclosed |
| WO-1993018026-A1 | INDOLE UREAS AS 5-HT1C RECEPTOR ANTOGONISTS | BEECHAM GROUP PLC (GB) | 1993-09-16 | — | — | WO | disclosed |
| CN-1076197-A | The preparation method of indole urea derivative | BEECHAM GROUP PLC (GB) | 1993-09-15 | — | — | CN | disclosed |
| EP-0550507-A1 | INDOLE UREAS AS 5 HT RECEPTOR ANTAGONIST | Beecham Group p.l.c. (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005170-A1 | INDOLE UREAS AS 5 HT RECEPTOR ANTAGONIST | BEECHAM GROUP PLC (GB) | 1992-04-02 | — | — | WO | disclosed |