Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.58 |
| ▸ | HTR1A | P08908 | 3/20 | 0.57 |
| ▸ | HTR7 | P34969 | 3/20 | 0.57 |
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
| ▸ | HTR3A | P46098 | 2/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.57 |
| ▸ | HTR1B | P28222 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.57 |
| ▸ | HTR3B | O95264 | 1/20 | 0.57 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.57 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.56 |
| ▸ | CASP1 | P29466 | 9/20 | 0.56 |
| ▸ | CASP7 | P55210 | 9/20 | 0.56 |
| ▸ | USP2 | O75604 | 7/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8785247 | 0.84 | ALDH1A1 (0.53) | HTR1AHTR7HTR2BHTR3AADRB1 | |
| SCHEMBL12911529 | 0.84 | TGFBR1 (0.57) | TGFBR1HTR1AHTR7HTR2BHTR3A | |
| SCHEMBL4582837 | 0.83 | HTR1A (0.54) | TGFBR1HTR1AHTR7HTR2BHTR3A | |
| Hydrochloric Acid SCHEMBL940806 | 0.82 | TGFBR1 (0.56) | TGFBR1HTR1AHTR7HTR2BHTR3A | |
| Hydrochloric Acid SCHEMBL15008176 | 0.82 | ALDH1A1 (0.56) | HTR1AHTR7HTR2BHTR3AADRB1 | |
| Hydrochloric Acid SCHEMBL17580657 | 0.82 | ALDH1A1 (0.56) | HTR1AHTR7HTR2BHTR3AADRB1 | |
| SCHEMBL25182342 | 0.81 | TAAR1 (0.68) | HTR1AHTR7HTR2BHTR3AADRB1 | |
| SCHEMBL4582832 | 0.80 | TAAR1 (0.49) | TGFBR1ADRB1ALDH1A1CYP1A2CASP1 | |
| SCHEMBL6787637 | 0.80 | HTR7 (0.54) | HTR1AHTR7HTR2BHTR3AHTR6 | |
| SCHEMBL9400849 | 0.80 | HTR3A (0.54) | HTR1AHTR7HTR2BHTR3AADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314884-A | Antidepressants, anxiolytic agents | TROPONWERKE GMBH & CO. (DE) | 1994-05-24 | — | — | US | disclosed |
| US-5187276-A | Anxiolytics, neuroleptics, antidepressants, and nootropic agents | TROPONWERKE GMBH & CO. KG. (DE) | 1993-02-16 | — | — | US | disclosed |
| US-4988809-A | CENTRAL NERVOUS SYSTEM | TROPONWERKE GMBH & CO., KG (DE) | 1991-01-29 | — | — | US | disclosed |
| EP-0129128-B1 | 2-PYRIMIDINYL-1-PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | Troponwerke GmbH & Co. KG (DE) | 1990-11-22 | — | — | EP | disclosed |
| US-4937343-A | NEUROLEPTICS OR ANTIDEPRESSANTS | TROPONWERKE GMBH & CO. KG (DE) | 1990-06-26 | — | — | US | disclosed |
| US-4818756-A | CENTRAL NERVOUS SYSTEM DISORDERS | TROPONWERKE GMBH & CO., KG (DE) | 1989-04-04 | — | — | US | disclosed |
| EP-0129128-A2 | 2-Pyrimidinyl-1-piperazine derivatives, process for their preparation and medicines containing them | Troponwerke GmbH & Co. KG (DE) | 1984-12-27 | — | — | EP | disclosed |