Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 7/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404369 | 0.88 | ALDH1A1 (0.42) | GRM5PTGDR2HTTALDH1A1L3MBTL1 | |
| SCHEMBL9404357 | 0.88 | USP30 (0.41) | GRM5PTGDR2PTGS1ALDH1A1POLB | |
| SCHEMBL9404353 | 0.87 | TP53 (0.40) | GRM5PTGDR2PTGS1HTT | |
| SCHEMBL9404510 | 0.84 | P2RX7 (0.44) | GRM5PTGDR2PTGS1 | |
| SCHEMBL7818013 | 0.69 | HPGD (0.42) | GRM5PTGDR2PTGS1HTTALDH1A1 | |
| Oxalic Acid SCHEMBL9404480 | 0.69 | NOTUM (0.43) | NOTUMHTTALDH1A1L3MBTL1POLB | |
| SCHEMBL9404328 | 0.66 | KDM4E (0.36) | GRM5PTGDR2HTTALDH1A1 | |
| SCHEMBL7817800 | 0.66 | HPGD (0.46) | PTGDR2PTGS1ALDH1A1 | |
| SCHEMBL9404352 | 0.63 | HPGD (0.43) | GRM5PTGDR2PTGS1ALDH1A1 | |
| SCHEMBL7469385 | 0.62 | HPGD (0.56) | PTGDR2PTGS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0316718-B1 | AZACYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-09-15 | — | — | EP | claimed |
| US-5356912-A | 3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease | NOVO NORDISK A/S (DK) | 1994-10-18 | — | — | US | disclosed |
| US-5262427-A | Cognition activators for Alzheimer*s disease | NOVO NORDISK A/S (DK) | 1993-11-16 | — | — | US | disclosed |
| EP-0316718-B1 | AZACYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-09-15 | — | — | EP | disclosed |
| EP-0316718-A2 | Azacyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1989-05-24 | — | — | EP | disclosed |