Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817800 | 0.85 | HPGD (0.46) | HPGDLMNAALDH1A1PTGDR2BLM | |
| SCHEMBL9625300 | 0.81 | FAAH (0.46) | LMNAALDH1A1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9404562 | 0.72 | PNMT (0.45) | HPGDALDH1A1SIGMAR1MEN1KMT2A | |
| SCHEMBL9404436 | 0.70 | MAOA (0.31) | — | |
| SCHEMBL7469385 | 0.70 | HPGD (0.56) | HPGDLMNAALDH1A1PTGDR2BLM | |
| SCHEMBL4279383 | 0.68 | HPGD (0.73) | HPGDLMNAALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL30277860 | 0.68 | HPGD (0.73) | HPGDLMNAALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL1114359 | 0.68 | HPGD (0.59) | HPGDALDH1A1BLMSIGMAR1 | |
| SCHEMBL7397925 | 0.68 | SIGMAR1 (0.49) | SIGMAR1MEN1KMT2A | |
| SCHEMBL1171232 | 0.68 | SIGMAR1 (0.49) | SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0316718-B1 | AZACYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-09-15 | — | — | EP | claimed |
| US-5356912-A | 3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease | NOVO NORDISK A/S (DK) | 1994-10-18 | — | — | US | disclosed |
| US-5262427-A | Cognition activators for Alzheimer*s disease | NOVO NORDISK A/S (DK) | 1993-11-16 | — | — | US | disclosed |
| EP-0316718-B1 | AZACYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-09-15 | — | — | EP | disclosed |
| EP-0316718-A2 | Azacyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1989-05-24 | — | — | EP | disclosed |