Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404510 | 0.71 | P2RX7 (0.44) | CYP3A4CYP2D6CYP2C19GRM5PTGS1 | |
| SCHEMBL7817800 | 0.70 | HPGD (0.46) | HPGDLMNACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9404261 | 0.69 | NOTUM (0.44) | GRM5PTGS1PTGDR2ALDH1A1HTT | |
| SCHEMBL9404369 | 0.69 | ALDH1A1 (0.42) | LMNAGRM5PTGDR2ALDH1A1HTT | |
| SCHEMBL4279383 | 0.68 | HPGD (0.73) | HPGDLMNACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL30277860 | 0.68 | HPGD (0.73) | HPGDLMNACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9404353 | 0.68 | TP53 (0.40) | LMNAGRM5PTGS1PTGDR2HTT | |
| SCHEMBL9404352 | 0.67 | HPGD (0.43) | HPGDLMNACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7817295 | 0.67 | ALDH1A1 (0.45) | HPGDLMNAGRM5PTGS1PTGDR2 | |
| SCHEMBL7469385 | 0.66 | HPGD (0.56) | HPGDLMNAPTGS1PTGDR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793665-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 2001-09-12 | — | — | EP | disclosed |
| US-5741788-A | TREATING DISEASES IN CENTRAL NERVOUS SYSTEM CAUSED BY MALFUNCTIONING OF MUSCARINIC CHOLINERGIC SYSTEM ESPECIALLY ALZHEIMER'S DISEASE | NOVO NORDISK A/S (DK) | 1998-04-21 | — | — | US | disclosed |
| EP-0793665-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016065-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1996-05-30 | — | — | WO | disclosed |