SCHEMBL9408539

SCHEMBL9408539

FC(F)(F)C(c1ccc(CBr)cc1)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
TRPA1 O75762 1/20 0.40
TSHR P16473 1/20 0.40
TAAR1 Q96RJ0 1/20 0.35
IDO1 P14902 3/20 0.34
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
PTPN1 P18031 2/20 0.32
GSK3B P49841 1/20 0.32
MAOB P27338 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
HSD17B10 Q99714 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
PGK1 P00558 1/20 0.31
PGK2 P07205 1/20 0.31
PTPN2 P17706 1/20 0.31
PTPN6 P29350 1/20 0.31
PTPN11 Q06124 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2823641 0.81 RORC (0.43) ALDH1A1TRPA1TSHRTAAR1IDO1
SCHEMBL8436560 0.81 ESR1 (0.50) ALDH1A1TRPA1TSHRTAAR1IDO1
SCHEMBL16875453 0.81 TRPA1 (0.40) ALDH1A1TRPA1TSHRTAAR1IDO1
SCHEMBL4229 0.80 TAAR1 (0.54) ALDH1A1TRPA1TSHRTAAR1IDO1
SCHEMBL16880438 0.77 ALDH1A1 (0.37) ALDH1A1TRPA1TSHRTAAR1IDO1
SCHEMBL15603600 0.77 PDE2A (0.47) ALDH1A1TRPA1TSHRTAAR1IDO1
SCHEMBL1512233 0.77 NR1H3 (0.52)
SCHEMBL16446207 0.76 ALDH1A1 (0.40) ALDH1A1TRPA1TSHRTAAR1IDO1
SCHEMBL15201569 0.76 ALDH1A1 (0.40) ALDH1A1TRPA1TSHRTAAR1IDO1
SCHEMBL2273601 0.74 MAOB (0.57) TAAR1IDO1PTPN1GSK3BMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0592306-A2 19F-MRI Contrast medium TERUMO KABUSHIKI KAISHA (JP) 1994-04-13 EP disclosed