SCHEMBL9408686

SCHEMBL9408686

COc1cc(OC)nc(SC(COC(=O)c2ccccc2C(=O)OCC(Sc2nc(OC)cc(OC)n2)C(C)(C)C)C(C)(C)C)n1

nearest known ligand 0.43

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.43
ALDH1A1 P00352 2/20 0.43
CA2 P00918 1/20 0.37
CYP3A4 P08684 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
ADRB2 P07550 1/20 0.37
ADRB1 P08588 1/20 0.37
ADRB3 P13945 1/20 0.37
HTR4 Q13639 1/20 0.36
EDNRB P24530 1/20 0.36
EDNRA P25101 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9408731 0.89 ADRB2 (0.43) ALDH1A1ADRB2ADRB1ADRB3EDNRB
SCHEMBL9408865 0.85 ALDH1A1 (0.39) ALDH1A1
SCHEMBL9408733 0.84 ALDH1A1 (0.38) ALDH1A1
SCHEMBL9408689 0.81 ALDH1A1 (0.36) ALDH1A1
SCHEMBL9408696 0.81 ALDH1A1 (0.36) ALDH1A1
SCHEMBL9408719 0.81
SCHEMBL9408634 0.80 ADORA3 (0.37) ALDH1A1EDNRBEDNRA
SCHEMBL9408609 0.80 TSHR (0.38) TSHRALDH1A1
SCHEMBL9408667 0.79 ALDH1A1 (0.33) ALDH1A1
SCHEMBL9408626 0.79 L3MBTL1 (0.36) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593998-A1 Pyrimidinylthioalkane herbicides NIHON BAYER AGROCHEM K.K. (JP) 1994-04-27 EP disclosed