Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 18/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 18/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606838 | 0.77 | AGTR1 (0.53) | AGTR1AGTR2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL6611120 | 0.76 | AGTR1 (0.55) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL6608915 | 0.76 | AGTR1 (0.42) | AGTR1AGTR2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL8552171 | 0.76 | MAP2K1 (0.40) | AGTR1AGTR2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL9409382 | 0.75 | KDM4E (0.39) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL6606990 | 0.73 | AGTR1 (0.57) | AGTR1AGTR2 | |
| SCHEMBL9424056 | 0.71 | AGTR1 (0.67) | AGTR1AGTR2 | |
| SCHEMBL7810041 | 0.69 | — | — | |
| SCHEMBL2730 | 0.68 | LTB4R2 (0.53) | AGTR1 | |
| SCHEMBL8553595 | 0.67 | LTB4R2 (0.45) | AGTR1AGTR2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588299-A2 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |