Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.62 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.60 |
| ▸ | HKDC1 | Q2TB90 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.58 |
| ▸ | CTSK | P43235 | 1/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL941092 | 1.00 | TOP2A (0.70) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL9319994 | 1.00 | TOP2A (0.70) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL28493225 | 0.98 | TOP2A (0.68) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL28494134 | 0.98 | TOP2A (0.68) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL22056136 | 0.84 | TOP2A (0.76) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL5526339 | 0.84 | NPC1 (0.63) | TOP2AHSP90AA1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10747534 | 0.84 | TOP2A (0.61) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL29378716 | 0.84 | NPC1 (0.63) | TOP2AHSP90AA1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL27178963 | 0.84 | TOP2A (0.70) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL800985 | 0.83 | AGTR1 (0.53) | TOP2AHKDC1SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 151 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197126-A | Novel NMNAT enzyme agonist and preparation and application thereof | 清华大学 | 2022-10-18 | — | — | CN | claimed |
| CN-110698512-B | Tin complex with 2-acetylpyridine thiosemicarbazone as ligand and synthesis method thereof | 广西师范大学 | 2021-09-24 | — | — | CN | claimed |
| CN-112062789-A | Palladium complex taking 2-acetylpyridine thiosemicarbazone as ligand and synthetic method thereof | 广西师范大学 | 2020-12-11 | — | — | CN | claimed |
| CN-112047980-A | Rhodium complex with 2-acetylpyridine thiosemicarbazone as ligand and synthesis method thereof | 广西师范大学 | 2020-12-08 | — | — | CN | claimed |
| CN-110698512-A | Tin complex with 2-acetylpyridine thiosemicarbazone as ligand and synthesis method thereof | 广西师范大学 | 2020-01-17 | — | — | CN | claimed |
| US-20170100352-A1 | Methods for treating or preventing neuroinflammation or autoimmune diseases | ELFORD HOWARD L (US) | 2017-04-13 | — | — | US | claimed |
| EP-2030615-A2 | Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases | ELFORD, Howard L. (US) | 2009-03-04 | — | — | EP | claimed |
| US-20090047250-A1 | Methods for treating or preventing neuroinflammation or autoimmune diseases | ELFORD HOWARD L | 2009-02-19 | — | — | US | claimed |
| US-4777166-A | DIOL VEHICLE; HERPES VIRUS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1988-10-11 | — | — | US | claimed |
| US-4596798-A | Herpes virus | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1986-06-24 | — | — | US | claimed |
| US-20240219131-A1 | SYSTEM AND METHODS FOR DETECTING FAILURE OF HEAT EXCHANGERS | PENTAIR WATER POOL AND SPA, INC. | 2024-07-04 | — | — | US | disclosed |
| WO-2024124297-A1 | ANTI-CANCER COMPOUNDS AND USES THEREOF | GRIFFITH UNIVERSITY (AU) | 2024-06-20 | — | — | WO | disclosed |
| US-11471497-B1 | Copper chelation therapeutics | BERMUDES DAVID GORDON (US) | 2022-10-18 | — | — | US | disclosed |
| CN-115197126-A | Novel NMNAT enzyme agonist and preparation and application thereof | 清华大学 | 2022-10-18 | — | — | CN | disclosed |
| CN-110698512-B | Tin complex with 2-acetylpyridine thiosemicarbazone as ligand and synthesis method thereof | 广西师范大学 | 2021-09-24 | — | — | CN | disclosed |
| US-4665173-A | ANTIMALARIAL, ANTILEUKEMIC | UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY | 1987-05-12 | — | — | US | disclosed |
| US-4657903-A | Transition metal complexes of the selenium analogs of 2-acetyl- and 2-propionylpyridine thiosemicarbazones useful for treating malarial infections and leukemia | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1987-04-14 | — | — | US | disclosed |
| US-4596798-A | Herpes virus | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1986-06-24 | — | — | US | disclosed |
| US-4596798-A | Herpes virus | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1986-06-24 | — | — | US | disclosed |
| US-4596798-A | Herpes virus | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1986-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090047250-A1 | Methods for treating or preventing neuroinflammation or autoimmune diseases | RNASE1, RNASEH1, TXNRD3 | TOP2A 2605/4885HSP90AA1 1149/4885SLC2A1 1918/4885 |
| US-20170100352-A1 | Methods for treating or preventing neuroinflammation or autoimmune diseases | RNASE1, RNASEH1, TXNRD3 | TOP2A 2605/4885HSP90AA1 1149/4885SLC2A1 1918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.