Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.62 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.60 |
| ▸ | HKDC1 | Q2TB90 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.58 |
| ▸ | CTSK | P43235 | 1/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL941093 | 1.00 | TOP2A (0.70) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL9319994 | 1.00 | TOP2A (0.70) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL28493225 | 0.98 | TOP2A (0.68) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL28494134 | 0.98 | TOP2A (0.68) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL22056136 | 0.84 | TOP2A (0.76) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL5526339 | 0.84 | NPC1 (0.63) | TOP2AHSP90AA1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10747534 | 0.84 | TOP2A (0.61) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL29378716 | 0.84 | NPC1 (0.63) | TOP2AHSP90AA1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL27178963 | 0.84 | TOP2A (0.70) | TOP2AHSP90AA1SLC2A1HKDC1SMN1; SMN2 | |
| SCHEMBL800985 | 0.83 | AGTR1 (0.53) | TOP2AHKDC1SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197126-A | Novel NMNAT enzyme agonist and preparation and application thereof | 清华大学 | 2022-10-18 | — | — | CN | claimed |
| WO-2020107221-A1 | CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF | TSINGHUA UNIVERSITY (CN) | 2020-06-04 | — | — | WO | disclosed |
| US-20190256460-A1 | (THIO, OXO AND SELENO) SEMICARBAZONE COMPLEXES WITH ZINC AND THEIR USE FOR TREATING CANCER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2019-08-22 | — | — | US | disclosed |
| US-10221133-B2 | (Thio, oxo, and seleno) semicarbazone complexes with zinc and their use for treating cancer | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2019-03-05 | — | — | US | disclosed |
| US-20180002279-A1 | (THIO, OXO, AND SELENO) SEMICARBAZONE COMPLEXES WITH ZINC AND THEIR USE FOR TREATING CANCER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2018-01-04 | — | — | US | disclosed |
| WO-2016123246-A1 | (THIO, OXO AND SELENO) SEMICARBAZONE COMPLEXES WITH ZINC AND THEIR USE FOR TREATING CANCER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-08-04 | — | — | WO | disclosed |
| US-8318782-B2 | Mitotic kinesin inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2012-11-27 | — | — | US | disclosed |
| US-20110275827-A1 | Mitotic Kinesin Inhibitor | FUJIFILM CORPORATION (JP) | 2011-11-10 | — | — | US | disclosed |
| EP-1454903-B9 | Thiadiazoline derivatives for treating cancer | KYOWA HAKKO KIRIN CO LTD (JP) | 2011-10-05 | — | — | EP | disclosed |
| EP-2327702-A1 | Mitotic kinesin inhibitor | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-06-01 | — | — | EP | disclosed |
| US-7759371-B2 | Thiadiazoline derivative | Kyowa Hakko Kinn Co., Ltd. (JP) | 2010-07-20 | — | — | US | disclosed |
| US-7425636-B2 | Thiadiazoline derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-09-16 | — | — | US | disclosed |
| US-20080207706-A1 | THIADIAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD (JP) | 2008-08-28 | — | — | US | disclosed |
| EP-1847534-A2 | Thiadiazoline derivative | Kyowa Hakko Kogyo Co., Ltd (JP) | 2007-10-24 | — | — | EP | disclosed |
| US-20070213380-A1 | Thiadiazoline derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-09-13 | — | — | US | disclosed |
| US-20070155804-A1 | Mitotic kinesin inhibitor | KYOWA HAKKO KOGYO CO., LTD. OF TOKYO, JAPAN FUJI PHOTO FILM CO., LTD. KANAGAWA, JAPAN | 2007-07-05 | — | — | US | disclosed |
| WO-2007062015-A2 | METHODS OF TREATING ISCHEMIC RELATED CONDITIONS | PANACEA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| US-20060074113-A1 | Thiadiazoline derivative | KYOWA KIRIN CO., LTD. (JP) | 2006-04-06 | — | — | US | disclosed |
| EP-1616866-A1 | M-STAGE KINESIN INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-01-18 | — | — | EP | disclosed |
| EP-1454903-A1 | THIADIAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2004-09-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060074113-A1 | Thiadiazoline derivative | BRWD1, RB1, ARG2 | TOP2A 217/4885HSP90AA1 288/4885SLC2A1 3201/4885 |
| US-20070155804-A1 | Mitotic kinesin inhibitor | KIF15, KIF5A, KIF5B | TOP2A 291/4885HSP90AA1 1114/4885SLC2A1 3944/4885 |
| US-20070213380-A1 | Thiadiazoline derivative | BRWD1, RB1, ARG2 | TOP2A 217/4885HSP90AA1 288/4885SLC2A1 3201/4885 |
| US-20190256460-A1 | (THIO, OXO AND SELENO) SEMICARBAZONE COMPLEXES WITH ZINC AND THEIR USE FOR TREATING CANCER | SLC39A3, SLC30A6, SLC39A11 | TOP2A 430/4885HSP90AA1 2413/4885SLC2A1 1088/4885 |
| US-20180002279-A1 | (THIO, OXO, AND SELENO) SEMICARBAZONE COMPLEXES WITH ZINC AND THEIR USE FOR TREATING CANCER | SLC39A3, SLC39A11, SLC39A7 | TOP2A 513/4885HSP90AA1 2072/4885SLC2A1 776/4885 |
| US-10221133-B2 | (Thio, oxo, and seleno) semicarbazone complexes with zinc and their use for treating cancer | SLC39A3, SLC39A11, SLC39A7 | TOP2A 513/4885HSP90AA1 2072/4885SLC2A1 776/4885 |
| US-20080207706-A1 | THIADIAZOLINE DERIVATIVE | BRWD1, RB1, ARG2 | TOP2A 217/4885HSP90AA1 288/4885SLC2A1 3201/4885 |
| US-20110275827-A1 | Mitotic Kinesin Inhibitor | KIF15, KIF5A, KIF5B | TOP2A 291/4885HSP90AA1 1114/4885SLC2A1 3944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.