Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 4/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9412454 | 0.89 | HDAC6 (0.40) | PDE3BPDE3AP2RY12PDE2AACACB | |
| SCHEMBL9412499 | 0.86 | PDE3B (0.52) | PDE3BPDE3AP2RY12PDE2ANPY1R | |
| SCHEMBL9412497 | 0.82 | CNR2 (0.42) | PDE3BPDE3AP2RY12PDE2AALDH1A1 | |
| SCHEMBL9412644 | 0.81 | PDE3B (0.35) | PDE3BPDE3AP2RY12PDE2AACACB | |
| SCHEMBL9412536 | 0.80 | ITGB3 (0.46) | SMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL9412664 | 0.79 | PDE3B (0.42) | PDE3BPDE3AP2RY12PDE2AALDH1A1 | |
| SCHEMBL9412731 | 0.77 | KDM4E (0.52) | ALDH1A1MEN1KMT2ARAB9ATP53 | |
| SCHEMBL9412511 | 0.77 | MAPT (0.45) | RAB9ALMNATP53SMN1; SMN2ITGB3 | |
| Bromide SCHEMBL9412485 | 0.76 | PDE3B (0.50) | PDE3BPDE3AP2RY12PDE2ANPY1R | |
| SCHEMBL9412623 | 0.74 | MAPT (0.46) | RAB9ASMN1; SMN2ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611660-A2 | Condensed 5-membered heterocycles, process for their preparation and medicines containing these compounds | Dr. Karl Thomae GmbH (DE) | 1994-08-24 | — | — | EP | disclosed |