Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.42 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9412477 | 0.91 | HDAC1 (0.42) | SMN1; SMN2TP53ADORA2AHDAC1CNR2 | |
| Bromide SCHEMBL9412639 | 0.91 | ITGB3 (0.51) | SMN1; SMN2TP53MAPTHDAC1ITGB3 | |
| SCHEMBL9412515 | 0.91 | JAK2 (0.47) | BCHECNR2BRD4ITGB3ITGA2B | |
| SCHEMBL9412609 | 0.91 | HDAC1 (0.44) | TP53HDAC1NPC1BRD4ITGB3 | |
| SCHEMBL9412544 | 0.90 | HDAC1 (0.48) | SMN1; SMN2TP53MAPTHDAC1HPGD | |
| SCHEMBL9412505 | 0.89 | TSHR (0.45) | HDAC1HPGDBRD4TSHR | |
| SCHEMBL9412623 | 0.88 | MAPT (0.46) | SMN1; SMN2MAPTNPC1BRD4ITGB3 | |
| SCHEMBL9412591 | 0.86 | MAPT (0.51) | SMN1; SMN2TP53MAPTHPGDNPC1 | |
| SCHEMBL9412586 | 0.85 | RORC (0.46) | HDAC1BRD4ITGB3ITGA2BITGA2 | |
| SCHEMBL9412665 | 0.85 | MAPT (0.45) | SMN1; SMN2MAPTNPC1BRD4ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611660-A2 | Condensed 5-membered heterocycles, process for their preparation and medicines containing these compounds | Dr. Karl Thomae GmbH (DE) | 1994-08-24 | — | — | EP | disclosed |