Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | FCER2 | P06734 | 6/20 | 0.43 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 5/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417266 | 0.86 | CTSS (0.53) | TACR2CTSLCTSBCTSS | |
| SCHEMBL7441871 | 0.86 | CTSS (0.53) | TACR2CTSLCTSBCTSS | |
| SCHEMBL9417413 | 0.85 | REN (0.51) | MMP8RENCTSLCTSS | |
| SCHEMBL7290351 | 0.85 | REN (0.51) | MMP8RENCTSLCTSS | |
| SCHEMBL7302163 | 0.83 | REN (0.48) | MMP8RENTACR2 | |
| SCHEMBL7281480 | 0.80 | MMP1 (0.43) | MMP8FCER2MMP1MMP9REN | |
| SCHEMBL10555105 | 0.78 | CTSL (0.56) | TACR2CTSLCTSBCTSS | |
| SCHEMBL9417383 | 0.78 | REN (0.39) | MMP8MMP9RENCTSLCTSS | |
| SCHEMBL9417279 | 0.77 | CTSS (0.40) | CTSLCTSBCTSS | |
| SCHEMBL7443340 | 0.76 | MMP8 (0.57) | MMP8MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229667-B1 | Peptidylaminodiols | ABBOTT LAB (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5214129-A | Amidation of a protected amino acid by an di-O-protected dihydroxy-containing amine and coupling with a carboxylic acid; deprotecting; renin inhibitors; hypotensive agents | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |
| US-5091575-A | Renin inhibitor | ABBOTT LABORATORIES (US) | 1992-02-25 | — | — | US | disclosed |
| US-4845079-A | HYPOTENSIVE, RENIN INHIBITION | ABBOTT LABORATORIES | 1989-07-04 | — | — | US | disclosed |