Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | DNM1 | Q05193 | 11/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9418670 | 1.00 | LMNA (0.62) | LMNAHTTDNM1HSP90AA1RAD52 | |
| Hydrochloric Acid SCHEMBL9418656 | 0.96 | LMNA (0.68) | LMNAHTTDNM1HSP90AA1RAD52 | |
| SCHEMBL18539514 | 0.94 | LMNA (0.70) | LMNAHTTDNM1HSP90AA1RAD52 | |
| SCHEMBL12412127 | 0.94 | LMNA (0.70) | LMNAHTTDNM1HSP90AA1RAD52 | |
| Hydrochloric Acid SCHEMBL9418686 | 0.85 | LMNA (0.53) | LMNAHTTDNM1HSP90AA1RAD52 | |
| SCHEMBL995736 | 0.84 | TSHR (0.42) | LMNADNM1KMT2A | |
| SCHEMBL114514 | 0.84 | TSHR (0.42) | LMNADNM1KMT2A | |
| SCHEMBL5843416 | 0.84 | TSHR (0.42) | LMNADNM1KMT2A | |
| SCHEMBL114288 | 0.84 | TSHR (0.42) | LMNADNM1KMT2A | |
| SCHEMBL4806782 | 0.84 | TSHR (0.42) | LMNADNM1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281414-A | Crosslinked organosilicon quarternary ammonium salt and ion exchange resin | STOCKEL RICHARD F (US) | 1994-01-25 | — | — | US | claimed |
| US-5281414-A | Crosslinked organosilicon quarternary ammonium salt and ion exchange resin | STOCKEL RICHARD F (US) | 1994-01-25 | — | — | US | disclosed |
| US-4921691-A | Spray on wound dressing compositions | STOCKEL RICHARD F (US) | 1990-05-01 | — | — | US | disclosed |
| US-4615882-A | NON ADSORBABLE ORGANOSILICON QUATERNARY AMMONIUM SALT BONDED TO WATER-SOLUBLE POLYMER | STOCKEL RICHARD F | 1986-10-07 | — | — | US | disclosed |