Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.43 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.43 |
| ▸ | CASP2 | P42575 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6904086 | 0.90 | HCAR2 (0.50) | ALOX15HCAR2PAOXALDH1A1TSHR | |
| Fumaric Acid SCHEMBL7796795 | 0.88 | HCAR2 (0.52) | HCAR2MEN1KMT2AALDH1A1TSHR | |
| Maleic Acid SCHEMBL9314759 | 0.88 | HCAR2 (0.52) | HCAR2MEN1KMT2AALDH1A1TSHR | |
| Fumaric Acid SCHEMBL6899442 | 0.88 | HCAR2 (0.52) | HCAR2MEN1KMT2AALDH1A1TSHR | |
| Maleic Acid SCHEMBL18628259 | 0.88 | HCAR2 (0.52) | HCAR2MEN1KMT2AALDH1A1TSHR | |
| Fumaric Acid SCHEMBL7796800 | 0.88 | HCAR2 (0.52) | HCAR2MEN1KMT2AALDH1A1TSHR | |
| Fumaric Acid SCHEMBL7796790 | 0.88 | HCAR2 (0.52) | HCAR2MEN1KMT2AALDH1A1TSHR | |
| Spermine SCHEMBL3060219 | 0.84 | CA12 (0.59) | ALOX15PAOXCASP2MEN1KMT2A | |
| Spermine SCHEMBL3060222 | 0.84 | CA12 (0.59) | ALOX15PAOXCASP2MEN1KMT2A | |
| Spermidine SCHEMBL3059084 | 0.82 | CA12 (0.61) | ALOX15PAOXCASP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5275848-A | Process for preparing a laminate of metal and a polyolefin resin | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1994-01-04 | — | — | US | disclosed |