Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.44 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL18628259 | 1.00 | HCAR2 (0.52) | HCAR2MEN1KMT2ATSHRTP53 | |
| Maleic Acid SCHEMBL9314759 | 1.00 | HCAR2 (0.52) | HCAR2MEN1KMT2ATSHRTP53 | |
| Fumaric Acid SCHEMBL7796795 | 1.00 | HCAR2 (0.52) | HCAR2MEN1KMT2ATSHRTP53 | |
| Fumaric Acid SCHEMBL7796790 | 1.00 | HCAR2 (0.52) | HCAR2MEN1KMT2ATSHRTP53 | |
| Fumaric Acid SCHEMBL6899442 | 1.00 | HCAR2 (0.52) | HCAR2MEN1KMT2ATSHRTP53 | |
| Fumaric Acid SCHEMBL28180759 | 0.93 | DNM1 (0.55) | HCAR2MEN1KMT2ATSHRDNM1 | |
| Dodecylamine SCHEMBL7596339 | 0.91 | DNM1 (0.59) | HCAR2MEN1KMT2ATSHRDNM1 | |
| Octadecylamine SCHEMBL28409810 | 0.91 | DNM1 (0.59) | HCAR2MEN1KMT2ATSHRDNM1 | |
| Dodecylamine SCHEMBL7596348 | 0.91 | DNM1 (0.59) | HCAR2MEN1KMT2ATSHRDNM1 | |
| Fumaric Acid SCHEMBL9420126 | 0.88 | ALOX15 (0.44) | HCAR2MEN1KMT2ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3144332-A1 | NEW TRIMER CATALYST ADDITIVES FOR IMPROVING FOAM PROCESSABILITY | AIR PRODUCTS AND CHEMICALS, INC. (US) | 2017-03-22 | — | — | EP | claimed |
| US-11085124-B2 | Electrochemical reaction device | KABUSHIKI KAISHA TOSHIBA (JP) | 2021-08-10 | — | — | US | disclosed |
| EP-1159334-A1 | PROCESS FOR THE MANUFACTURE OF FUNCTIONALIZED POLYPHENYLENE ETHERS | GENERAL ELECTRIC COMPANY (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000064973-A1 | COMPOSITIONS OF STYRENIC BLOCK COPOLYMER RESIN AND POLYPHENYLENE ETHER RESIN | GENERAL ELECTRIC COMPANY (US) | 2000-11-02 | — | — | WO | disclosed |
| WO-2000046274-A1 | PROCESS FOR THE MANUFACTURE OF FUNCTIONALIZED POLYPHENYLENE ETHERS | GENERAL ELECTRIC COMPANY (US) | 2000-08-10 | — | — | WO | disclosed |