Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ADH1B | P00325 | 1/20 | 0.46 |
| ▸ | ADH1C | P00326 | 1/20 | 0.46 |
| ▸ | ADH1A | P07327 | 1/20 | 0.46 |
| ▸ | ADH7 | P40394 | 1/20 | 0.46 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL11249013 | 0.91 | ALDH1A1 (0.56) | HCAR2TSHRALDH1A1ADH1BADH1C | |
| Fumaric Acid SCHEMBL11249020 | 0.91 | ALDH1A1 (0.56) | HCAR2TSHRALDH1A1ADH1BADH1C | |
| Fumaric Acid SCHEMBL9420126 | 0.90 | ALOX15 (0.44) | HCAR2TSHRALDH1A1ALOX15ADH1B | |
| Fumaric Acid SCHEMBL21145333 | 0.85 | TSHR (0.47) | HCAR2TSHRALDH1A1ADH1BADH1A | |
| Fumaric Acid SCHEMBL21145335 | 0.85 | TSHR (0.47) | HCAR2TSHRALDH1A1ADH1BADH1A | |
| Bicarbonate SCHEMBL28699185 | 0.85 | TSHR (0.58) | TSHRALDH1A1ALOX15ADH1BADH1C | |
| Bicarbonate SCHEMBL910039 | 0.85 | TSHR (0.58) | TSHRALDH1A1ALOX15ADH1BADH1C | |
| Sorbic Acid SCHEMBL11374488 | 0.84 | ACHE (0.46) | HCAR2TSHRALDH1A1ALOX15ADH1B | |
| Fumaric Acid SCHEMBL18696155 | 0.84 | ALDH1A1 (0.48) | HCAR2TSHRALDH1A1ADH1BADH1C | |
| Sorbic Acid SCHEMBL11374490 | 0.84 | ACHE (0.46) | HCAR2TSHRALDH1A1ALOX15ADH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200230854-A1 | ADHESIVE AND METHOD OF BONDING TO RIGID SUBSTRATES | LORD CORP (US) | 2020-07-23 | — | — | US | disclosed |
| WO-2018152497-A1 | ADHESIVE AND METHOD OF BONDING TO RIGID SUBSTRATES | LORD CORPORATION (US) | 2018-08-23 | — | — | WO | disclosed |
| WO-2013004646-A1 | LAMINATE FOR PACKAGING | UNILEVER N.V. (NL) | 2013-01-10 | — | — | WO | disclosed |
| EP-0864610-B1 | Semiaromatic polyamide resin composition | MITSUI CHEMICALS INC (JP) | 2004-01-21 | — | — | EP | disclosed |
| EP-0758675-B1 | Adhesive polypropylene resin composition and multi-layer laminate body using the resin composition | MITSUI CHEMICALS INC (JP) | 2001-01-31 | — | — | EP | disclosed |
| US-6117942-A | GRAFT-MODIFIED ETHYLENE-ALPHA OLEFIN COPOLYMER, A POLYTEREPHTHALAMIDE EXHIBITS EXCELLENT ANTI-CREEPING PROPERTY UNDER HIGH-TEMPERATURE AND HIGH-HUMIDITY CONDITIONS, MOLDING MATERIAL | MITSUI CHEMICALS (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-0864610-A1 | Semiaromatic polyamide resin composition | Mitsui Chemicals, Inc. (JP) | 1998-09-16 | — | — | EP | disclosed |
| US-5695838-A | GRAFT-MODIFIED WITH UNSATURATED ACID AND ACID ANHYDRIDE; IMPROVED ADHESION | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-09 | — | — | US | disclosed |
| EP-0758675-A2 | Adhesive polypropylene resin composition and multi-layer laminate body using the resin composition | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |
| EP-0479561-B1 | Process for heat-treating a polyolefin coating on metal in the presence of a treating agent | MITSUI PETROCHEMICAL IND (JP) | 1995-08-23 | — | — | EP | disclosed |
| US-5275848-A | Process for preparing a laminate of metal and a polyolefin resin | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1994-01-04 | — | — | US | disclosed |
| EP-0479561-A2 | Process for heat-treating a polyolefin coating on metal in the presence of a treating agent | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-04-08 | — | — | EP | disclosed |