Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 3/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL941854 | 0.94 | ALDH1A1 (0.40) | ALDH1A1NPC1RAB9ASMN1; SMN2USP2 | |
| SCHEMBL942160 | 0.94 | MAPT (0.39) | ALDH1A1NPC1RAB9ASMN1; SMN2USP2 | |
| SCHEMBL943062 | 0.93 | ALDH1A1 (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2USP2 | |
| SCHEMBL942744 | 0.92 | MAPT (0.40) | ALDH1A1NPC1RAB9ASMN1; SMN2USP2 | |
| SCHEMBL942186 | 0.92 | NPC1 (0.38) | ALDH1A1NPC1RAB9ASMN1; SMN2USP2 | |
| SCHEMBL945771 | 0.85 | SLC2A1 (0.39) | ALDH1A1NPC1RAB9ASMN1; SMN2USP2 | |
| SCHEMBL942897 | 0.85 | F13A1 (0.38) | ALDH1A1NPC1RAB9ASMN1; SMN2USP2 | |
| SCHEMBL1991189 | 0.85 | MAPT (0.40) | ALDH1A1NPC1RAB9ASMN1; SMN2GBA1 | |
| SCHEMBL944101 | 0.83 | ALDH1A1 (0.38) | ALDH1A1NPC1RAB9ASMN1; SMN2USP2 | |
| SCHEMBL944212 | 0.83 | NPC1 (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524705-B2 | 2-oxo-2-(2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl)-acetamide derivatives and related compounds as antifungal agents | F2G LIMITED BRITISH BODY CORPORATE (GB) | 2013-09-03 | — | — | US | claimed |
| US-20110009390-A1 | 2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS | F2G LIMITED (GB) | 2011-01-13 | — | — | US | claimed |
| US-8524705-B2 | 2-oxo-2-(2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl)-acetamide derivatives and related compounds as antifungal agents | F2G LIMITED BRITISH BODY CORPORATE (GB) | 2013-09-03 | — | — | US | disclosed |
| US-20110009390-A1 | 2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS | F2G LIMITED (GB) | 2011-01-13 | — | — | US | disclosed |
| EP-2173749-B1 | 2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS | F2G LTD (GB) | 2011-01-12 | — | — | EP | disclosed |
| US-7781423-B2 | Compounds to promote regeneration of bone marrow | CANCURE LABORATORIES, LLC (US) | 2010-08-24 | — | — | US | disclosed |
| EP-2173749-A1 | 2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS | F2G Limited (GB) | 2010-04-14 | — | — | EP | disclosed |
| US-20090004136-A1 | COMPOUNDS TO PROMOTE REGENERATION OF BONE MARROW | ZOLTAN LABORATORIES LLC (US) | 2009-01-01 | — | — | US | disclosed |
| WO-2008145963-A1 | 2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS | F2G LIMITED (GB) | 2008-12-04 | — | — | WO | disclosed |
| US-20080234234-A1 | COMPOUNDS TO PROMOTE REGENERATION OF BONE MARROW | ZOLTAN LABORATORIES, LLC (US) | 2008-09-25 | — | — | US | disclosed |
| US-7423029-B1 | from endogenous or exogenous stem/progenitor cells and to normalize blood cell and platelet counts; e.g. [3-(3,4-dimethyl-9-oxo-9H-thioxanthen-2-yloxy)-2-hydroxypropyl]trimethylammonium chloride; antitumor and AIDS agent; low toxicity, side effect reduction | ZOLTAN LABORATORIES, LLC (US) | 2008-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090004136-A1 | COMPOUNDS TO PROMOTE REGENERATION OF BONE MARROW | PDGFA, BMP4, BMP2 | ALDH1A1 1400/4885NPC1 3908/4885RAB9A 1501/4885 |
| US-20080234234-A1 | COMPOUNDS TO PROMOTE REGENERATION OF BONE MARROW | PDGFA, BMP4, BMP2 | ALDH1A1 1400/4885NPC1 3908/4885RAB9A 1501/4885 |
| US-20110009390-A1 | 2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS | NAT1, FOXM1, CYP51A1 | ALDH1A1 124/4885NPC1 678/4885RAB9A 2441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.