SCHEMBL1991189

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1644920	0.85	MAPT (0.42)	MAPTSMN1; SMN2RGS12CYP1A2CYP3A4
	SCHEMBL942149	0.85	ALDH1A1 (0.38)	MAPTSMN1; SMN2RGS12CYP1A2CYP3A4
	SCHEMBL1647637	0.83	MAPT (0.40)	MAPTSMN1; SMN2RGS12CYP1A2CYP3A4
	SCHEMBL1993791	0.81	TRPV1 (0.38)	MAPTSMN1; SMN2RGS12CYP1A2CYP3A4
	SCHEMBL30234731	0.81	MAPT (0.42)	MAPTCYP1A2CYP3A4CYP2D6KDM4E
	SCHEMBL1127284	0.81	MAPT (0.42)	MAPTCYP1A2CYP3A4CYP2D6KDM4E
	SCHEMBL1992685	0.80	MAPT (0.43)	MAPTSMN1; SMN2CYP1A2CYP3A4CYP2D6
	SCHEMBL2232068	0.80	MAPT (0.39)	MAPTSMN1; SMN2CYP1A2CYP3A4CYP2D6
	SCHEMBL1646827	0.79	RAB9A (0.37)	MAPTSMN1; SMN2KDM4EALDH1A1RAB9A
	SCHEMBL1989247	0.79	MAPT (0.40)	MAPTSMN1; SMN2CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.