Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9383407 | 0.83 | KCNJ1 (0.61) | KCNH2KCNJ1MAOASIGMAR1 | |
| SCHEMBL9428430 | 0.81 | SMN1; SMN2 (0.60) | HTR1AKCNH2KCNJ1ADRA1DADRA1A | |
| SCHEMBL17884143 | 0.71 | LMNA (0.54) | — | |
| SCHEMBL5745400 | 0.71 | KCNJ1 (0.61) | KCNH2KCNJ1USP2HTR2AHTR2C | |
| SCHEMBL9429342 | 0.71 | DRD3 (0.56) | HTR1ASMN1; SMN2HTR2ADRD2SIGMAR1 | |
| SCHEMBL9428318 | 0.70 | MEN1 (0.54) | ADRA1DADRA1AADRA1B | |
| SCHEMBL20818756 | 0.70 | KMT2A (0.50) | ADRA1DADRA1AADRA1BSMN1; SMN2TSHR | |
| SCHEMBL9428716 | 0.69 | ALDH1A1 (0.52) | HTR1AADRA1DADRA1AADRA1BSMN1; SMN2 | |
| SCHEMBL9428246 | 0.69 | MEN1 (0.52) | HTR1AADRA1DADRA1AADRA1BHTR2A | |
| SCHEMBL9428322 | 0.69 | SLC6A3 (0.57) | HTR1AKCNH2HTR2ADRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332739-A | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-07-26 | — | — | US | disclosed |
| EP-0454498-A2 | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-10-30 | — | — | EP | disclosed |