Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | HRH2 | P25021 | 3/20 | 0.50 |
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428476 | 0.89 | ALDH1A1 (0.58) | DRD2MAPTHTR1AHRH2HRH1 | |
| SCHEMBL9428373 | 0.89 | DRD2 (0.58) | DRD2MAPTHTR1AHRH2HRH1 | |
| SCHEMBL9429324 | 0.89 | DRD2 (0.56) | DRD2HTR1AHRH2HRH1HTR2A | |
| SCHEMBL9428466 | 0.89 | MEN1 (0.49) | DRD2HTR1AHRH1HTR2AMEN1 | |
| SCHEMBL9429006 | 0.89 | HRH1 (0.60) | DRD2HTR1AHRH2HRH1HTR2A | |
| Hydrochloric Acid SCHEMBL9428228 | 0.88 | SIGMAR1 (0.55) | DRD2HTR1AHRH2HRH1HTR2A | |
| Hydrochloric Acid SCHEMBL9429118 | 0.88 | MEN1 (0.48) | DRD2MAPTHTR1AHRH1HTR2A | |
| Hydrochloric Acid SCHEMBL9428467 | 0.88 | DRD2 (0.57) | DRD2MAPTHTR1AHRH2HRH1 | |
| SCHEMBL9428870 | 0.87 | HRH3 (0.57) | HRH2HRH1MEN1ALDH1A1KMT2A | |
| SCHEMBL9429325 | 0.87 | HRH1 (0.51) | DRD2HTR1AHRH2HRH1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332739-A | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-07-26 | — | — | US | disclosed |
| EP-0454498-A2 | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-10-30 | — | — | EP | disclosed |