Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.41 |
| ▸ | HRH1 | P35367 | 8/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | HRH2 | P25021 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429396 | 0.89 | HRH3 (0.46) | HRH3HRH1HRH2HTR1AHTR2A | |
| SCHEMBL9428874 | 0.89 | HRH1 (0.45) | HRH3HRH1DRD2HTR1AHTR2A | |
| SCHEMBL9429002 | 0.88 | HRH3 (0.45) | HRH3HRH1HRH2 | |
| SCHEMBL9428911 | 0.86 | HRH1 (0.41) | HRH3HRH1HRH2DRD2HTR1A | |
| SCHEMBL9428763 | 0.84 | KCNA5 (0.48) | HRH1DRD2HTR1AADRA1DADRA1A | |
| SCHEMBL9386087 | 0.84 | HTR1A (0.43) | HRH3HRH1MAOBHRH2HTR1A | |
| SCHEMBL9428459 | 0.83 | KCNA5 (0.41) | HRH3HRH1MAOBHRH2HTR1A | |
| SCHEMBL9428870 | 0.79 | HRH3 (0.57) | HRH3HRH1HRH2 | |
| SCHEMBL9428883 | 0.78 | HRH1 (0.50) | HRH3HRH1HRH2DRD2HTR1A | |
| SCHEMBL9429393 | 0.78 | HRH3 (0.43) | HRH3HRH1HRH2DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332739-A | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-07-26 | — | — | US | disclosed |
| EP-0454498-A2 | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-10-30 | — | — | EP | disclosed |