Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 13/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428763 | 0.96 | KCNA5 (0.48) | HRH1KCNA5DRD2DRD1DRD3 | |
| SCHEMBL9429396 | 0.92 | HRH3 (0.46) | HRH1HRH3HTR1AHTR2A | |
| SCHEMBL9429002 | 0.90 | HRH3 (0.45) | HRH1HRH3 | |
| SCHEMBL9428996 | 0.89 | HRH3 (0.41) | HRH1HRH3DRD2HTR1AADRA1D | |
| SCHEMBL9428911 | 0.87 | HRH1 (0.41) | HRH1HRH3DRD2DRD3HTR1A | |
| SCHEMBL9429278 | 0.84 | HRH1 (0.45) | HRH1KCNA5HTR1AADRA1DADRA1A | |
| SCHEMBL9383925 | 0.84 | ALDH1A1 (0.49) | HRH1DRD2DRD1DRD3HTR1A | |
| SCHEMBL9428459 | 0.84 | KCNA5 (0.41) | HRH1HRH3KCNA5DRD3HTR1A | |
| SCHEMBL9429623 | 0.83 | ALDH1A1 (0.48) | HRH1KCNA5DRD2DRD3ADRA1D | |
| SCHEMBL9428145 | 0.82 | HRH1 (0.45) | HRH1HRH3DRD2DRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332739-A | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-07-26 | — | — | US | disclosed |
| EP-0454498-A2 | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-10-30 | — | — | EP | disclosed |